Areas of Treatment

InterVene Inc. is developing an innovative device to recanalize and debulk chronic postthrombotic tissue in s instent restenosis, postthrombotic venous stenting, late DVT thrombectomy, and in-flow vein restoration settings.

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Chronic Venous Insufficiency Findings

In patients with significant preexisting postthrombotic disease, primary patency was 59% at 1 year and 51% at 2 years. 43% had reinterventions during the follow-up, and median time to re-intervention was 32 days.1

In a series of nearly 5000 patients treated over an 18 year period at a pioneering center of excellence, the majority (69%) of stent occlusions were identified as chronic.2

Varied levels of ISR have been reported to develop in >70% of patients who have undergone iliofemoral venous stenting, and ISR accounts for ≥83% of the reinterventions in iliofemoral venous stents.3

Treatment of underlying venous obstruction has been reported to occur in excess of 50% to 60% in patients  after thrombolysis.4

The majority of patients with in-stent restenosis (78.6%) were observed to have complete occlusions of their deep veins before stenting.5

Patients who require recanalization of a completely occluded venous outflow tract before stenting have had a high rate of early re-occlusion, with 25.5% of stents failing in 3 months.6

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An American Heart Association report from 2021 estimated that approximately 1,220,000 total cases of VTE (Pulmonary Embolism and Deep Vein Thrombosis) occur in the USA annually. Postthrombotic syndrome is a common complication of Deep Vein Thrombosis and develops in 20-50% of patients. 7

Inflow disease accounts for the largest proportion of stent failures following both the index procedure and subsequent intervention.8

Flow-related issues were observed in 43.8% of the reintervention cases and no cases not requiring reintervention.9

1Two Year Outcome After Chronic Iliac Vein Occlusion Recanalisation Using the Vici Venous Stent
Eur J Vasc Endovasc Surg. 2018 Nov;56(5):710-718. doi: 10.1016/j.ejvs.2018.07.014. Epub 2018 Aug 20. PMID: 30139572.
1Black S, Gwozdz A, Karunanithy N, Silickas J, Breen K, Hunt B, Smith A, Cohen A, Saha P.

2Characteristics and outcomes of stent occlusion after iliocaval stenting
Arjun Jayaraj, William Crim, Alexander Knight, Seshadri Raju, Journal of Vascular Surgery: Venous and Lymphatic Disorders, Volume 7, Issue 1,2019, Pages 56-64,

3An overview of in-stent restenosis in iliofemoral venous stents
Taimur Saleem, Seshadri Raju:, Journal of Vascular Surgery: Venous and Lymphatic Disorders, Volume 10, Issue 2,2022, Pages 492-503.e2

4Venous Outflow Obstruction
Endovascular Today, February 2011, By Antonios P. Gasparis, Md, Rvt, Facs, And Nicos Labropoulos, Phd, Dic, Rvt

5A meta-analysis of the medium- to long-term outcomes in patients with chronic deep venous disease treated with dedicated venous stents.
Arshpreet Singh Badesha, Stephen Alan Black, Ghazn Khan, Alexander James Harper, Narayanan Thulasidasan, Andrew Doyle, Taha Khan, Journal of Vascular Surgery: Venous and Lymphatic Disorders, Volume 12, Issue 3, 2024,

6Early thrombosis after iliac stenting for venous outflow occlusion is related to disease severity and type of anticoagulation
Marston WA, Browder SE, Iles K, Griffith A, McGinigle KL.. J Vasc Surg Venous Lymphat Disord. 2021 Nov;9(6):1399-1407.e1. doi: 10.1016/j.jvsv.2021.02.012. Epub 2021 Mar 2. PMID: 33667740; PMCID: PMC10066803.

7Epidemiology and prevention of venous thromboembolism
Lutsey PL, Zakai NA. Nat Rev Cardiol. 2023 Apr;20(4):248-262. doi: 10.1038/s41569-022-00787-6. Epub 2022 Oct 18. PMID: 36258120; PMCID: PMC9579604.

8Classification of Stent Failure and Risk Factors for Further Reintervention in Patients Treated for Deep Venous Obstruction
ABSTRACT| VOLUME 12, ISSUE 3, 101778, MAY 2024, Ehsanul Choudhury, Rachael Morris, Anna Pouncey, Kanoklada Srikuea, Bhavesh Natha, Narayanan Thulasidasan, Narayan Karunanithy, Taha Khan, Stephen Black

9Risk factors and classification of reintervention following deep venous stenting for acute iliofemoral deep vein thrombosis.
Pouncey AL, Kahn T, Morris RI, Saha P, Thulasidasan N, Black SA. J Vasc Surg Venous Lymphat Disord. 2022 Sep;10(5):1051-1058.e3. doi: 10.1016/j.jvsv.2022.03.006. Epub 2022 Mar 28. PMID: 35358730.